Coach Rolando DeLa Barrera's Pioneers, 20-10 on the season, will play Northeastern Oklahoma at 2 p.m. Thursday at Oklahoma Baptist University.
Western is the number four seed on the west side of the region while NEO is the top seed on the east side of the region.
If Western defeats NEO they will play the Seminole-Arkansas-Fort Smith winner at 1 p.m. Saturday. Seminole and Forth Smith will play at 6 p.m. Sunday.
Other first round games has Redlands, the second ranked team in the country, playing Connors at 8 p.m. Thursday and Eastern facing Northern of Tonkawa at 1 p.m. Thursday.
It's been a resurgence year for the Pioneers who recorded their first 20-win season in 26 years.
The Western Oklahoma State College Lady Pioneers are in the playoffs by the luck of a coin flip.
Regional officials originally made an error in calculating a tie-breaker between Western and Murray State for the final playoff spot.
The matter was settled Monday afternoon when Western coach Janice Hardwick won a coin flip via telephone.
The Lady Pioneers, the fourth seed in the west, will play Arkansas-Fort Smith, the number one seed in the east. That game will tip off at 3 p.m. Friday at OBU.
Other first round games has Northern of Tonkawa and Carl Albert playing at 1 p.m. on Friday.
On the other side of the bracket NEO will meet Northern of Enid at 6 p.m. and Seminole will play Connors at 8 p.m.